LA LABResearch Reference Document
Compound Guide
Selank — Anxiolytic Tuftsin Analogue (TP-7)
Quick Start
What It Is
Selank (also designated TP-7) is a synthetic heptapeptide developed by the Institute of Molecular Genetics of the Russian Academy of Sciences. It is a tuftsin analogue (tuftsin = immunomodulatory tetrapeptide Thr-Lys-Pro-Arg) extended with additional amino acids to improve stability. Approved in Russia as a prescription drug for generalised anxiety disorder and neurasthenia.
Research Dosing
SubQ: 250–500 mcg/day. Intranasal: 600–2,700 mcg/day split into 2–3 administrations. The intranasal route is favoured in Russian clinical research; SubQ is more common in Western research contexts. Half-life is short (~1–3 min plasma, but effects persist longer due to downstream signalling).
Cycle Structure
4 weeks on / 4 weeks off for SubQ protocols. Intranasal research protocols typically use 14–21 day courses followed by a washout period before resuming. The on/off structure is used to prevent tolerance.
Regulatory Status
Approved prescription drug in Russia for anxiety and neurasthenia. No FDA approval. No ClinicalTrials.gov Phase 1–3 program registered as of 2026. Not on WADA banned list. For research purposes only outside Russia.
Dosing Protocol
| Route | Dose | Frequency | Duration | Notes |
|---|---|---|---|---|
| SubQ | 250–500 mcg | Once daily | 4 weeks on, 4 weeks off | Western research standard |
| Intranasal | 200–900 mcg per administration | 2–3× daily | 14–21 day course + washout | Russian clinical standard; 2–3 sprays of 200–300 mcg each |
Supplies & Reconstitution (SubQ)
Reconstitution Math — 11 mg Vial (3 mL BAC)
| Target Dose | Units (U-100) | Doses / Vial |
|---|---|---|
| 100 mcg | 2.7 units | 110 |
| 200 mcg | 5.5 units | 55 |
| 300 mcg | 8.2 units | 36.7 |
| 500 mcg | 13.6 units | 22 |
| 600 mcg | 16.4 units | 18.3 |
| 1000 mcg | 27.3 units | 11 |
Reconstitute the 11 mg vial with 3.0 mL bacteriostatic water → 3.67 mg/mL (3,667 mcg/mL). U-100 syringe = 100 units per mL. Swirl gently — do not shake. Refrigerate 2–8°C.
Reconstitution Steps
01
Warm the vial
Allow lyophilised vial to reach room temperature before reconstitution.
02
Swab and draw
Alcohol swab both vial tops. Draw required BAC water volume.
03
Inject along the wall
Run BAC water slowly along the inside vial wall. Do not jet onto the powder.
04
Swirl gently
Swirl until clear and fully dissolved. Do not shake.
05
Refrigerate
Store at 2–8°C for up to 30 days. Do not freeze after reconstitution. Protect from light.
Mechanism of Action
GABA Modulation
Modulates GABAergic transmission — the primary inhibitory neurotransmitter system. Proposed to enhance GABA-A receptor sensitivity without direct agonism, producing anxiolytic effects without benzodiazepine-like dependence or sedation in research models.
Serotonin System
Influences serotonin turnover and 5-HT receptor activity in limbic brain regions. Studied in animal anxiety models (elevated plus maze, Vogel conflict test). Not a direct serotonin agonist.
Enkephalin Stabilisation
Inhibits enzymatic degradation of endogenous enkephalins (endogenous opioid peptides), prolonging their activity. Enkephalins modulate stress response and pain sensitivity in the brain and peripheral nervous system.
BDNF Expression
Increases Brain-Derived Neurotrophic Factor (BDNF) expression in hippocampus and cortex in animal models. BDNF is associated with neuroplasticity, memory consolidation, and resilience to stress.
Research Status
Limited Independent Replication
Published Selank research consists primarily of studies from Russian academic institutions. No Phase 1–3 trials are registered on ClinicalTrials.gov as of mid-2026. Independent replication in Western research contexts is very limited. The quality and publication standards of available studies vary widely.
| Study Type | Finding | Limitation |
|---|---|---|
| Russian RCTs (anxiety) | Reduced anxiety scores vs placebo; comparable to benzodiazepines in some measures | Russian-only journals; limited independent replication |
| Animal models | Anxiolytic in elevated plus maze; memory-enhancing in learning paradigms | Animal-to-human extrapolation unestablished |
| Gene expression studies | BDNF upregulation; IL-6 modulation observed | In vitro and animal; no human confirmation |
Storage
| State | Temperature | Duration | Notes |
|---|---|---|---|
| Lyophilised (powder) | −20°C (freezer) | Up to 24 months | Protect from light and moisture |
| Reconstituted (liquid) | 2–8°C (refrigerator) | Up to 30 days | Do not freeze after reconstitution |
Disclaimer
This document is an educational research reference only. Selank is not FDA-approved. Published human data is primarily from Russian sources and has not been independently replicated in Western Phase 1–3 trials. By purchasing from LA LAB you confirm you are 18+ and that products are for research purposes only.